IMPA1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18668
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | IMP 1,IMP,IMPA 1,IMPA,IMPA1,IMPA1,IMPase 1,IMPase,Inositol 1(or 4) monophosphatase,Inositol monophosphatase 1,Inositol monophosphatase,Inositol(myo) 1(or 4) monophosphatase 1,Inositol-1(or 4)-monophosphatase 1,Lithium sensitive myo inositol monophosphatase A1,Lithium-sensitive myo-inositol monophosphatase A1,IMPA1抗体 |
| Swissprot | P29218 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human IMPA1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. |
Images
Western blot analysis of Human cerebrum tissue lysate using IMPA1 Polyclonal Antibody at dilution of 1:360
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using IMPA1 Polyclonal Antibody at dilution of 1:25(×200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using IMPA1 Polyclonal Antibody at dilution of 1:25(×200)
