IMPDH2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11330
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | IMDH2,IMP (inosine monophosphate) dehydrogenase 2,IMP dehydrogenase 2,IMP oxireductase 2,IMPD 2,IMPD2,IMPDH 2,IMPDH II,IMPDH-II,Impdh2,Inosine 5' monophosphate dehydrogenase 2,Inosine 5' phosphate dehydrogenase 2,Inosine monophosphate dehydrogenase type II,Inosine-5''-monophosphate dehydrogenase 2,IMPDH2抗体 |
| Swissprot | P12268 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human IMPDH2 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytosol,Extracellular region or secreted,extracellular exosome,extracellular region,Nucleus,Peroxisome,peroxisomal membrane,Other locations:cytoplasm,ficolin-1-rich granule lumen,membrane,secretory granule lumen |
| Tissue specificity | IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. |
Images
Western Blot analysis of A549 cell using IMPDH2 Polyclonal Antibody at dilution of 1:650
Immunohistochemistry of paraffin-embedded Human lung cancer using IMPDH2 Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human liver cancer using IMPDH2 Polyclonal Antibody at dilution of 1:60
