IPO4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11331
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Imp4,Imp4b,Importin 4,Importin 4b,Importin-4,Importin-4b,Ipo4,IPO4,Ran binding protein 4,Ran-binding protein 4,RanBP4,IPO4抗体 |
| Swissprot | Q8TEX9 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human IPO4 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Importin-4 is a protein that in humans is encoded by the IPO4 gene.Functions in nuclear protein import as nuclear transport receptor.Serves as receptor for nuclear localization signals (NLS) in cargo substrates.Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism.At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. |
Images
Western Blot analysis of Hela cell and Human testis tissue, A549, Jurkat and K562 cell using IPO4 Polyclonal Antibody at dilution of 1:550
Immunohistochemistry of paraffin-embedded Human colon cancer using IPO4 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human prostate cancer using IPO4 Polyclonal Antibody at dilution of 1:50
