ITGA2B Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22101
宿主: Mouse
反应性: H
应用: IHC-p
Overview
| Synonyms | antigen CD41,BDPLT16,BDPLT2,CD41,CD41B,form 2,GP2B,GPalpha IIb,GPIIb,GT,GTA,HPA3,Integrin alpha 2b,Integrin alpha IIb,Integrin alpha-IIb light chain,Integrin,alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex,antigen CD41),ITA2B,Itga2b,ITGAB,platelet fibrinogen receptor,alpha subunit,platelet glycoprotein IIb of IIb/IIIa complex,Platelet membrane glycoprotein IIb,platelet specific antigen BAK,PPP1R93,CD41抗体 |
| Swissprot | P08514 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Synthetic Peptide |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Membrane. |
| Tissue specificity | Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Clone No | Clone:5D1 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
