ITGA2B Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15138
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | antigen CD41,BDPLT16,BDPLT2,CD41,CD41B,form 2,GP2B,GPalpha IIb,GPIIb,GT,GTA,HPA3,Integrin alpha 2b,Integrin alpha IIb,Integrin alpha-IIb light chain,Integrin,alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex,antigen CD41),ITA2B,Itga2b,ITGAB,platelet fibrinogen receptor,alpha subunit,platelet glycoprotein IIb of IIb/IIIa complex,Platelet membrane glycoprotein IIb,platelet specific antigen BAK,PPP1R93,ITGA2B抗体 |
| Swissprot | P08514 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human ITGA2B |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. |
| Tissue specificity | Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. |
