ITGB3BP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10402
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Beta 3 endonexin,Beta3 endonexin,Beta3 endonexin long form,CENP R,CENPR,CENPR,Centromere protein R,endonexin,Beta-3,HSU37139,Integrin beta 3 binding protein (beta3-endonexin),Integrin beta 3 binding protein,NRIF 3,NRIF3,Nuclear receptor interacting factor 3,TAP 20,TAP20,ITGB3BP抗体 |
| Swissprot | Q13352 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human ITGB3BP |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Note=Localizes in the centromeres. Isoform 3 is predominantly nuclear and weakly cytoplasmic. |
| Tissue specificity | Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants. |
