ITPR2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18139
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | 4,5-trisphosphate receptor,Inositol 1 4 5 trisphosphate receptor type 2,Inositol 1,4,5-trisphosphate receptor type 2,Inositol 145 trisphosphate receptor type 2,InsP3 R2,InsP3R2,IP3 R2,IP3 receptor,IP3 receptor isoform 2,IP3R 2,IP3R2,ITPR 2,Itpr2,ITPR2,Type 2 inositol 1 4 5 trisphosphate receptor,Type 2 inositol 1,Type 2 inositol 145 trisphosphate receptor,Type 2 InsP3 receptor,ITPR2抗体 |
| Swissprot | Q14571 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human ITPR2 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.86mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver. |
