KCNQ4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-16544
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | DFNA 2,DFNA2,KCNQ 4,Kcnq4,KCNQ4,KQT like 4,KQT-like 4,KV7.4,Potassium channel KQT like 4,Potassium channel subunit alpha KvLQT4,Potassium voltage gated channel KQT like protein 4,Potassium voltage gated channel KQT like subfamily member 4,Potassium voltage gated channel subfamily KQT member 4,Potassium voltage-gated channel subfamily KQT member 4,Voltage gated potassium channel subunit Kv7.4,Voltage-gated potassium channel subunit Kv7.4,KCNQ4抗体 |
| Swissprot | P56696 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human KCNQ4 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:200-1:1000;IHC,,1:50-1:200; |
| Concentration | 0.9 mg/mL |
| Clonality | Polyclonal |
Properties
| Tissue specificity | Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Background | The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. |
Images
Western Blot analysis of Human fetal brain and Mouse brain tissue using KCNQ4 Polyclonal Antibody at dilution of 1:200
Immunohistochemistry of paraffin-embedded Human liver cancer using KCNQ4 Polyclonal Antibody at dilution of 1:40
Immunohistochemistry of paraffin-embedded Human brain using KCNQ4 Polyclonal Antibody at dilution of 1:40
