KLF1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-19799
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | CDAN4,EKLF,EKLF PEN,Erythroid krueppel like transcription factor (EKLF) (Erythroid transcription factor),Erythroid krueppel-like transcription factor,Erythroid Kruppel like factor,Erythroid specific transcription factor EKLF,HBFQTL6,Human erythroid-specific transcription factor EKLF mRNA complete cds,INLU,Klf1,KLF1,Krueppel-like factor 1,Kruppel like factor 1 (erythroid),KLF1抗体 |
| Swissprot | Q13351 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human KLF1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:100 |
| Concentration | 0.96mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Colocalizes with SUMO1 in nuclear speckles. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.KLF1 (Kruppel Like Factor 1) is a Protein Coding gene. Diseases associated with KLF1 include Dyserythropoietic Anemia, Congenital, Type Iv and Hereditary Persistence Of Fetal Hemoglobin-Sickle Cell Disease Syndrome. Among its related pathways are Hematopoietic Stem Cell Differentiation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is KLF4. |
