KLK7 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14181
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | Chymotryptic stratum corneum,hK 7,hK7,hSCCE,Kallikrein 7 (chymotryptic stratum corneum),Kallikrein related peptidase 7,Kallikrein-7,Kallikrein7,KLK 7,Klk7,KLK7,Protease serine 6,PRSS 6,PRSS6,SCCE,Serine protease 6,Signal protein,Stratum corneum chymotryptic enzyme,KLK7抗体 |
| Swissprot | P49862 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human KLK7 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front. |
| Tissue specificity | Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. |
Images
Western Blot analysis of Mouse brain and kidney tissue using KLK7 Polyclonal Antibody at dilution of 1:600
Immunohistochemistry of paraffin-embedded Human esophagus cancer using KLK7 Polyclonal Antibody at dilution of 1:10
Immunohistochemistry of paraffin-embedded Human colon cancer using KLK7 Polyclonal Antibody at dilution of 1:10
