LEP Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70170
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | FLJ94114,LEP,LEP,LEPD,Leptin (murine obesity homolog),Leptin (obesity homolog,mouse),Leptin,Leptin Murine Obesity Homolog,Leptin Precursor Obesity Factor,OB,Obese protein,Obese,mouse,homolog of,Obesity,Obesity factor,Obesity homolog mouse,Obesity Murine Homolog Leptin,OBS,OTTHUMP00000212285,LEP抗体 |
| Swissprot | P41159,P41160,P50596 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Leptin |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100 |
| Concentration | 210 μg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Adipose tissue is the main source of leptin it is also produced by other peripheral tissues such as the skeletal muscle (PubMed:7789654, PubMed:16052473, PubMed:12448771). Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts (PubMed:12448771). Detected by fundic epithelium of the gastric mucosa (PubMed:10896907). Secreted into blood and gastric juice (PubMed:10896907). |
| Tissue specificity | Adipose tissue is the main source of leptin. It is also produced by other peripheral tissues such as the skeletal muscle. Expressed by intercalated and striated tracts of submandibular and parotid salivary gland intralobular ducts. Detected by fundic epithelium of the gastric mucosa. Secreted into blood and gastric juice.Highest expression level in adipose tissue of abdominal region. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. |
Images
Immunohistochemistry analysis of paraffin-embedded human colon using LEP Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded human stomach using LEP Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded mouse liver using LEP Polyclonal Antibody at dilution of 1:100.
Immunohistochemistry analysis of paraffin-embedded Rat lung using LEP Polyclonal Antibody at dilution of 1:100.
