Lipocalin-2/NGAL Polyclonal Antibody(Capture/Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000090P
货期：咨询
宿主: Rabbit
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | LCN2;HNL;NGAL;NeutrophiL geLatinase-associated LipocaLin;25 kDa aLpha-2-microgLobuLin-reLated subunit of MMP-9;LipocaLin-2;Oncogene 24p3;SiderocaLin;p25 |
| Swissprot | P80188 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Lipocalin-2/NGAL protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Iron-trafficking protein involved in multiple processes such as apoptosis,innate immunity and renal development.Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA),a siderophore that shares structural similarities with bacterial enterobactin,and delivers or removes iron from the cell,depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SlC22A17 (24p3R) receptor,leading to release of iron and subsequent increase of intracellular iron concentration. In contrast,association of the iron-free form (apo-24p3) with the SlC22A17 (24p3R) receptor is followed by association with an intracellular siderophore,iron chelation and iron transfer to the extracellular medium,thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (Il3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis,while iron-free form decreases intracellular iron levels,inducing expression of the proapoptotic protein BCl2l11/BIM,resulting in apoptosis.Involved in innate immunity,limits bacterial proliferation by sequestering iron bound to microbial siderophores,such as enterobactin.Can also bind siderophores from M.tuberculosis. |
