LRP5 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15758
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | BMND1,EVR1,EVR4,HBM,Low density lipoprotein receptor related protein 5,Low density lipoprotein receptor related protein 7,Low-density lipoprotein receptor-related protein 5,LR3,LRP-5,Lrp5,LRP5,LRP7,OPPG,OPS,OPTA1,Osteoporosis pseudoglioma syndrome,VBCH2,LRP5抗体 |
| Swissprot | O75197 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human LRP5 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 1.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. Endoplasmic reticulum. Chaperoned to the plasma membrane by MESD. |
| Tissue specificity | Widely expressed, with the highest level of expression in the liver. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. |
