MAFA Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53394
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | HMafA,Mafa,MAFA,Pancreatic beta cell specific transcriptional activator,Pancreatic beta-cell-specific transcriptional activator,RIPE3b1,Transcription factor MafA,Transcription factor RIPE3b1,v maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian),v maf musculoaponeurotic fibrosarcoma oncogene homolog A,V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,MAFA抗体 |
| Swissprot | Q8NHW3 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human MAFA |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 1.2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Detected in nuclei of pancreas islet beta cells. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members.MAFA acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. |
