MARK1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14680
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | KIAA1477,MAP/microtubule affinity regulating kinase 1,MAP/microtubule affinity-regulating kinase 1,MARK 1,MARK,Mark1,MARK1,MGC126512,MGC126513,Serine/threonine protein kinase MARK1,Serine/threonine-protein kinase MARK1,MARK1抗体 |
| Swissprot | Q9P0L2 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MARK1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton. Appears to localize to an intracellular network. |
| Tissue specificity | Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | MAP/microtubule affinity-regulating kinase 1 (MARK1) is a 795 amino acid protein belonging to the CAMK Ser/Thr protein kinase family. MARK1 is thought to play a role in the stability of the microtubule matrix of the cytoskeleton. MARK1 is activated by phosphorylation of Thr215 by LKB1 in complex with STRAD and MO25. Localized to the cytoskeleton, MARK1 contains one kinase-associated (KA1) domain, one protein kinase domain and one UBA domain. Expressed as three isoforms produced by alternative splicing, MARK1 is found with highest levels in brain, skeletal muscle and heart. |
