MCAM Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-53284
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | A32 antigen,CD 146,CD146,CD146 antigen,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Gicerin,Mcam,Melanoma adhesion molecule,Melanoma associated antigen A32,Melanoma associated antigen MUC18,Melanoma associated glycoprotein MUC18,Melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18,MelCAM,MUC 18,MUC18,MUC18,S endo 1,S endo 1 endothelial associated antigen,S-endo 1 endothelial-associated antigen,MCAM抗体 |
| Swissprot | P43121 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human MCAM |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:40-1:200; |
| Concentration | 1.14mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Membrane. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | CD146,also known as melanoma cell adhesion molecule (MCAM) or MUC18,originally identified as a biomarker of melanoma progression,is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily . Structurally,it consists of five Ig domains,a transmembrane domain,and a cytoplasmic region. In normal adult tissue,CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis,and has been used as marker of circulating endothelium cells (CECs) . |
Images
Western blot analysis of Human leiomyosarcoma tissue lysate using MCAM Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MCAM Polyclonal Antibody at dilution of 1:40(×200)
Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using MCAM Polyclonal Antibody at dilution of 1:40(×200)
