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MCM10 Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-18238

宿主: Rabbit

反应性: H,M

应用: IHC

  • 详情
  • Overview

    Synonyms Minichromosome Maintenance 10 Replication Initiation Factor,Minichromosome Maintenance Complex Component 10,Protein MCM10 Homolog,HsMCM10, MCM10 Minichromosome Maintenance Deficient 10 ,Homolog Of Yeast MCM10,PRO2249,CNA43,DNA43,MCM10抗体
    Swissprot Q7L590
    Source Rabbit
    Reactivity Human, Mouse
    Immunogen Fusion protein of human MCM10
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:30-1:150
    Concentration 0.6mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Nucleus
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
    Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
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