MCM6 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14210
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | DNA replication licensing factor MCM6,MCG40308,Mcm6,MCM6 minichromosome maintenance deficient 6 (MIS5 homolog,S. pombe),MCM6 minichromosome maintenance deficient 6,MCM6,Minichromosome maintenance complex component 6,Minichromosome maintenance deficient (mis5 S. pombe) 6,Minichromosome maintenance deficient 6 homolog,Minichromosome maintenance protein 6,Mis5,MIS5 homolog,p105MCM,MCM6抗体 |
| Swissprot | Q14566 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MCM6 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300; |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Binds to chromatin during G1 and detach from it during S phase. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. |
Images
Western Blot analysis of 293T, A549, Raji, K562 and NIH/3T3 cell using MCM6 Polyclonal Antibody at dilution of 1:433.3
Immunohistochemistry of paraffin-embedded Human esophagus cancer using MCM6 Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human colon cancer using MCM6 Polyclonal Antibody at dilution of 1:60
