MGMT Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40155
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | 6 O methylguanine DNA methyltransferase,6-O-methylguanine-DNA methyltransferase,Agat,AGT,AI267024,EC 2.1.1.63,Methylated DNA protein cysteine methyltransferase,Methylated-DNA--protein-cysteine methyltransferase,Methylguanine DNA methyltransferase,MGC107020,MGMT,MGMT,O 6 methylguanine DNA alkyltransferase,O 6 methylguanine DNA methyltransferase,O-6-methylguanine-DNA methyltransferase,O-6-methylguanine-DNA-alkyltransferase,MGMT抗体 |
| Swissprot | P16455 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant human Methylated DNA protein cysteine methyltransferase protein |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:1000; |
| Concentration | 2mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Highest expression level in liver |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4 |
| Background | Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. |
