MGP Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18763
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Cell growth inhibiting gene 36 protein,Cell growth-inhibiting gene 36 protein,GAMMA-CARBOXYGLUTAMIC ACID PROTEIN,MATRIX,GIG36,Matrix Gla protein,MGLAP,MGP,MGP,NTI,MGP抗体 |
| Swissprot | P08493 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human MGP |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:70-1:350; |
| Concentration | 1.32mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Matrix Gla protein (MGP) is is a vitamin K-dependent,extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP),which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS),which is an autosomal recessive disorder characterized by abnormal cartilage calcification,peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. |
