Mineralocorticoid receptor Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70261
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Aldosterone receptor,MCR,MGC133092,Mineralocorticoid receptor,MLR,MR,NR3 C2,NR3C2,NR3C2 protein,Nuclear receptor subfamily 3 group C member 2,Mineralocorticoid receptor抗体 |
| Swissprot | P08235,Q8VII8,P22199 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Mineralocorticoid receptor |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:800 |
| Concentration | 1.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus |
| Tissue specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes.Highest expression level in colonic mucosa. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. |
Images
Immunohistochemistry analysis of paraffin-embedded human stomach using Mineralocorticoid receptor Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse kidney using Mineralocorticoid receptor Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded rat kidney using Mineralocorticoid receptor Polyclonal Antibody at dilution of 1:300.
