MKKS Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11401
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Bardet Biedl syndrome 6 protein,Bardet-Biedl syndrome 6 protein,BBS6,HMCS,KMS,McKusick Kaufman syndrome,McKusick Kaufman/Bardet Biedl syndromes putative chaperonin,McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin,Mkks,MKKS,MKS,MKKS抗体 |
| Swissprot | Q9NPJ1 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human MKKS |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm>cytoskeleton>centrosome. Cytoplasm>cytosol. The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome. |
| Tissue specificity | Widely expressed in adult and fetal tissues. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. |
