MMP12 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14217
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | EC 3.4.24.65,HME,Macrophage elastase,Macrophage metalloelastase,Macrophage metaloelastase,Matrix metallopeptidase 12 (macrophage elastase),Matrix metalloprotease 12,Matrix metalloproteinase-12,ME,MGC138506,MME,MMP 12,MMP-12,Mmp12,MMP12,MMP12抗体 |
| Swissprot | P39900 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant protein of human MMP12 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. |
| Tissue specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. |
