MMP25 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15779
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Leukolysin,matrix metallopeptidase 25,matrix metallopeptidase like 1,matrix metalloproteinase 20,Matrix Metalloproteinase 25,Matrix metalloproteinase 25 precursor,Matrix metalloproteinase-25,Membrane type 6 Matrix Metalloproteinase,Membrane type Matrix Metalloproteinase 6,Membrane-type matrix metalloproteinase 6,Membrane-type-6 matrix metalloproteinase,MMP 25,MMP-25,MMP20,MMP20A,MMP25,MMP25,MMPL1,MT-MMP 6,MT6-MMP,MT6MMP,MTMMP6,MMP25抗体 |
| Swissprot | Q9NPA2 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP25 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Secreted, extracellular space, extracellular matrix. |
| Tissue specificity | Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. |
Images
Western Blot analysis of 823 cell using MMP25 Polyclonal Antibody at dilution of 1:1300
Immunohistochemistry of paraffin-embedded Human lung cancer using MMP25 Polyclonal Antibody at dilution of 1:80
Immunohistochemistry of paraffin-embedded Human liver cancer using MMP25 Polyclonal Antibody at dilution of 1:80
