MMP8 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15777
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | CLG 1,CLG1,Collagenase 1,Collagenase 1 neutrophil,HNC,Matrix metallopeptidase 8 (neutrophil collagenase),Matrix metalloprotease 8,Matrix metalloproteinase-8,MMP 8,MMP-8,Mmp8,MMP8,Neutrophil collagenase,PMNL CL,PMNL collagenase,PMNL-CL,PMNLCL,MMP8抗体 |
| Swissprot | P22894 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human MMP8 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:25-1:100; |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasmic granule. Secreted>extracellular space>extracellular matrix. Stored in intracellular granules. |
| Tissue specificity | Neutrophils. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. |
Images
Western Blot analysis of 231 cell using MMP8 Polyclonal Antibody at dilution of 1:800
Immunohistochemistry of paraffin-embedded Rat lung using MMP8 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human ovarian cancer using MMP8 Polyclonal Antibody at dilution of 1:45
