MRE11 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15211
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | AT like disease,Ataxia telangiectasia disorder like,ATLD,DNA recombination and repair protein,Double strand break repair protein MRE11A,Double-strand break repair protein MRE11A,endo/exonuclease Mre11,HNGS1,meiotic recombination (S. cerevisiae) 11 homolog A,Meiotic recombination 11 homolog 1,meiotic recombination 11 homolog A (S. cerevisiae),Meiotic recombination 11 homolog A,MmMRE11A,Mre 11,MRE 11a,MRE 11b,MRE11 homolog 1,MRE11 homolog A,MRE11 homolog double strand break repair nuclease,MRE11 meiotic recombination 11 homolog A (S. cerevisiae),MRE11 meiotic recombination 11 homolog A,MRE11,MRE11A,MRE11b,OTTHUMP00000236830,OTTHUMP00000236831,OTTHUMP00000236832,OTTHUMP00000236833,MRE11A抗体 |
| Swissprot | P49959 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MRE11A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-1:300 |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. Localizes to discrete nuclear foci after treatment with genotoxic agents. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
