NARF Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18713
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | DKFZp434G0420,FLJ10067,GC17P078009,IOP2,Iron only hydrogenase like protein 2,Nuclear prelamin A recognition factor,Prenyl dependent prelamin A binding protein,NARF抗体 |
| Swissprot | Q9UHQ1 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Fusion protein of human NARF |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:300 |
| Concentration | 1.56mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nuclear |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends.Prenylation was initially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importance in protein-protein interactions.The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif.This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A.The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain.It may be a component of a prelamin A endoprotease complex.The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina.It shares limited sequence similarity with iron-only bacterial hydrogenases.Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. |
