NBR1 Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22148
宿主: Mouse
反应性: H,M,R
应用: IHC-p,IF
Overview
| Synonyms | 1A1 3B,1A13B,B box protein,Cell migration-inducing gene 19 protein,KIAA0049,M17S2,Membrane component chromosome 17 surface marker 2,Membrane component,chromosome 17,surface marker 2 (ovarian carcinoma antigen CA125),MIG 19,MIG19,Migration inducing protein 19,NBR 1,Nbr1,NBR1,autophagy cargo receptor,NBR1,Neighbor of BRCA1 gene 1,Neighbor of BRCA1 gene 1 protein,Next to BRCA1 gene 1 protein,Ovarian carcinoma antigen CA125,Protein 1A1-3B,NBR1 Mouse (7C3)抗体 |
| Swissprot | Q14596 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Protein of NBR1 |
| Application | IHC-p(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC,,1:50-300;IF,,1:50-1:200; |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm. Cytoplasmic vesicle>autophagosome. Lysosome. Cytoplasm>myofibril>sarcomere>M line. In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. |
| Clone No | Clone:4C6 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.4 |
| Background | The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding. |
