NECTIN4 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-11438
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | DKFZp686K05193,EDSS1,Ig superfamily receptor LNIR,Nectin 4,Nectin-4,poliovirus receptor-related 4,Processed poliovirus receptor-related protein 4,PRR4,pvrl4,PVRL4,PVRL4抗体 |
| Swissprot | Q96NY8 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human PVRL4 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:100-1:300; |
| Concentration | 0.9 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. Cell junction>adherens junction. Colocalizes with MLLT4 at cadherin-based adherens junctions and Secreted. The secreted form is found in breast tumor patients. |
| Tissue specificity | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. |
Images
Western Blot analysis of SKOV3 cell using NECTIN4 Polyclonal Antibody at dilution of 1:350
Immunohistochemistry of paraffin-embedded Human liver cancer using NECTIN4 Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human lung cancer using NECTIN4 Polyclonal Antibody at dilution of 1:60
Immunohistochemistry of paraffin-embedded Human Placenta using NECTIN4 Polyclonal Antibody at dilution of 1:90(Elabscience® Product Detected by Lifespan).
Immunohistochemistry of paraffin-embedded Human Skin using NECTIN4 Polyclonal Antibody at dilution of 1:90(Elabscience® Product Detected by Lifespan).
