NEDD4L Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15252
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | E3 ubiquitin protein ligase NEDD4 like protein,E3 ubiquitin-protein ligase NEDD4-like,KIAA0439,NED4L,NEDD4 2,NEDD4 2c,Nedd4-2,NEDD4-2a,NEDD4.2,NEDD4b,NEDD4L,NEDD4La,NEDD4Lb,NEDD4Lc,NEDD4Ld,NEDD4Le,NEDD4Lf,NEDD4Lg,NEDD4Lh,NEDL3,Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase,Neural precursor cell expressed,developmentally down regulated 4 like,RSP5,Ubiquitin protein ligase Rsp5,NEDD4L抗体 |
| Swissprot | Q96PU5 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human NEDD4L |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 1 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. May be recruited to exosomes by NDFIP1. |
| Tissue specificity | Ubiquitously expressed, with highest levels in prostate, pancreas and kidney. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases.HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation.The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC.Single nucleotide polymorphisms in this gene may be associated with essential hypertension. |
