NFATC2 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12800
宿主: Rabbit
反应性: H,M
应用: WB
Overview
| Synonyms | AI607462,cytoplasmic 2,KIAA0611,NF ATc2,NF ATp,NF-ATc2,NF-ATp,NFAC2,NFAT 1,NFAT pre existing subunit,NFAT pre-existing subunit,NFAT transcription complex,preexisting component,NFAT1,NFAT1-D,NFATc2,NFATp,Nuclear factor of activated T cells cytoplasmic 2,Nuclear factor of activated T cells cytoplasmic calcineurin dependent 2,Nuclear factor of activated T cells pre-existing component,Nuclear factor of activated T cells,preexisting component,Nuclear factor of activated T-cells,Preexisting nuclear factor of activated T cells 2,T cell transcription factor NFAT 1,T-cell transcription factor NFAT1,NFATC2抗体 |
| Swissprot | Q13469 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Synthetic peptide of human NFATC2 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.7 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. |
| Tissue specificity | Expressed in thymus, spleen, heart, testis, brain, placenta, muscle and pancreas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. |
