NGEF Polyclonal Antibody
规格: | / 20μL / 60μL / 120μL / 200μL |
价格: | / ¥420 / ¥1010 / ¥1640 / ¥2365 |
货号:E-AB-18859
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
Synonyms | ARHGEF27,Eph receptor-interacting exchange protein,Eph-interacting exchange protein,EPHEXIN,Ephexin-1,Guanine nucleotide exchange factor, neuronal,Neuronal guanine nucleotide exchange factor,Ngef,NGEF,NGEF抗体 |
Swissprot | Q8N5V2 |
Source | Rabbit |
Reactivity | Human,Mouse,Rat |
Immunogen | Fusion protein of human NGEF |
Application | IHC(Detection kit: E-IR-R213) |
Recommended dilution | IHC,,1:40-1:200 |
Concentration | 0.6mg/mL |
Clonality | Polyclonal |
Properties
Cellular localization | Cytoplasm. Membrane. Cell projection>growth cone. Associated with membranes. Localizes to axonal growth cones. |
Isotype | IgG |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Background | Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). |