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NGEF Polyclonal Antibody

规格: / 20μL / 60μL / 120μL / 200μL
价格: / ¥420 / ¥1010 / ¥1640 / ¥2365

货号:E-AB-18859

宿主: Rabbit

反应性: H,M,R

应用: IHC

  • 详情
  • Overview

    Synonyms ARHGEF27,Eph receptor-interacting exchange protein,Eph-interacting exchange protein,EPHEXIN,Ephexin-1,Guanine nucleotide exchange factor, neuronal,Neuronal guanine nucleotide exchange factor,Ngef,NGEF,NGEF抗体
    Swissprot Q8N5V2
    Source Rabbit
    Reactivity Human,Mouse,Rat
    Immunogen Fusion protein of human NGEF
    Application IHC(Detection kit: E-IR-R213)
    Recommended dilution IHC,,1:40-1:200
    Concentration 0.6mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Cytoplasm. Membrane. Cell projection>growth cone. Associated with membranes. Localizes to axonal growth cones.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
    Background Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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