NIPBL Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18915
宿主: Rabbit
反应性: H,M
应用: IHC
Overview
| Synonyms | CDLS,Colon tumor susceptibility 2,Delangin,DKFZp434L1319,FLJ11203,FLJ12597,FLJ13354,FLJ13648,FLJ44854,IDN 3,IDN 3 protein,IDN 3 protein isoform A,IDN 3 protein isoform B,IDN 3B,IDN3 B,IDN3 protein,IDN3 protein isoform A,IDN3 protein isoform B,IDN3B,Mis 4,Mis4,Nipbl,NIPBL,Nipped B homolog (Drosophila),Nipped B homolog,Nipped B like,Nipped B like protein,Nipped-B-like protein,Scc 2,SCC 2 homolog,Scc2,SCC2 homolog,Sister chromatid cohesion protein Mis4,NIPBL抗体 |
| Swissprot | Q6KC79 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NIPBL |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.9mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. |
