NLRP6 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13438
宿主: Rabbit
反应性: H
应用: IHC
Overview
| Synonyms | Angiotensin II/vasopressin receptor,AVR,CLR11.4,NACHT,leucine rich repeat and PYD containing 6,NACHT,LRR and PYD containing protein 6,NACHT,LRR and PYD domains-containing protein 6,NAVR,NAVR/AVR,NLR family,pyrin domain containing 6,Nlrp6,NLRP6,Nucleotide binding oligomerization domain,leucine rich repeat and pyrin domain containing 6,PAN3,PYPAF5,PYRIN containing APAF1 like protein 5,PYRIN-containing APAF1-like protein 5,NLRP6抗体 |
| Swissprot | P59044 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human NLRP6 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Inflammasome. Cell membrane. Nucleus membrane. |
| Tissue specificity | Expressed in peripheral blood leukocytes, predominantly in granulocytes and, at lower levels, in CD4(+) and CD8(+) T-cells. Expressed in colonic myofibroblasts (at protein level) (PubMed:21593405). |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. |
