NME1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10491
宿主: Rabbit
反应性: H,M,R
应用: WB
Overview
| Synonyms | AWD,AWD,drosophila,homolog of,GAAD,Granzyme A activated DNase,Granzyme A-activated DNase,GZMA activated DNase,Metastasis inhibition factor NM23,NB,NBS,NDK A,NDKA,NDKA,NDP kinase A,NDPK-A,NDPKA,NM23,NM23 long variant,included,nm23-H1,NM23-M1,NM23H1B,included,NME/NM23 nucleoside diphosphate kinase 1,Nme1,NME1-NME2 spliced read-through transcript,included,Non-metastatic cells 1,protein (NM23A) expressed in,Nonmetastatic cells 1,protein expressed in,Nonmetastatic protein 23,Nonmetastatic protein 23,homolog 1,Nucleoside diphosphate kinase A,Tumor metastatic process-associated protein,NME1抗体 |
| Swissprot | P15531 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human NME1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:1000-1:5000; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA. |
| Tissue specificity | Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation. Isoform 3 is ubiquitously expressed. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. |
