NOX4 Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70215
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | Kidney oxidase 1,Kidney oxidase-1,Kidney superoxide producing NADPH oxidase,Kidney superoxide-producing NADPH oxidase,KOX 1,KOX,Kox-1,KOX1,NADPH,NADPH oxidase 4,Nox4,NOX4,Renal NAD(P)H oxidase,Renal NAD(P)H-oxidase,RENOX,NOX4抗体 |
| Swissprot | Q9NPH5,Q9JHI8,Q924V1 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse NOX4 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:1000-1:2000;IHC,,1:400-1:1000; |
| Concentration | 0.9 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Endoplasmic reticulum membrane. Cell membrane. Cell junction>focal adhesion. Nucleus. May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus. |
| Tissue specificity | Expressed by distal tubular cells in kidney cortex and in endothelial cells (at protein level). Widely expressed. Strongly expressed in kidney and to a lower extent in heart, adipocytes, hepatoma, endothelial cells, skeletal muscle, brain, several brain tumor cell lines and airway epithelial cells.Highest expression level in nephron tubule. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants. |
Images
Western Blot analysis of various samples using NOX4 Polyclonal Antibody at dilution of 1:1000.
Immunohistochemistry analysis of parafffin-embedded human kidney using NOX4 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of parafffin-embedded mouse kidney using NOX4 Polyclonal Antibody at dilution of 1:400.
