NRG1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-13305
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | Acetylcholine receptor-inducing activity,Acetylcholine receptor-inducing activity,CHICK,homolog of,ARIA,Breast cancer cell differentiation factor p45,GGF,GGF2,Glial growth factor,Heregulin,heregulin,alpha (45kD,ERBB2 p185-activator),HGL,HRG,HRG1,HRGA,MST131,NDF,Neu differentiation factor,Neuregulin 1,neuregulin 1 type IV beta 1a,neuregulin 1 type IV beta 3,Neuregulin-1,NRG 1,nrg1,NRG1-IT2,NRG1,OTTHUMP00000225398,OTTHUMP00000225419,OTTHUMP00000225420,OTTHUMP00000225421,OTTHUMP00000225422,OTTHUMP00000225477,OTTHUMP00000225545,OTTHUMP00000230603,OTTHUMP00000230605,pro-neuregulin-1,membrane-bound isoform,Pro-NRG1,ProNRG1,Sensory and motor neuron-derived factor,SMDF,NRG1抗体 |
| Swissprot | Q02297 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human NRG1 |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.8 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted; Cell membrane. Does not seem to be active; Membrane. May possess an internal uncleaved signal sequence; Nucleus. May be nuclear and Secreted. Has a signal peptide. |
| Tissue specificity | Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. This protein is a signaling protein that mediates cell-cell interactions and plays critical roles in the growth and development of multiple organ systems. It is known that an extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are tissue-specifically expressed and differ significantly in their structure, and thereby these isoforms are classified into types I, II, III, IV, V and VI. The gene dysregulation has been linked to diseases such as cancer, schizophrenia and bipolar disorder (BPD). |
