p70 S6 kinase alpha Monoclonal Antibody
| 规格： | / 20μL / 60μL / 120μL |
| 价格： | / ￥580 / ￥1420 / ￥2310 |
货号：E-AB-22198
宿主: Mouse
反应性: H,M,R
应用: IHC-p
Overview
| Synonyms | 70 kDa ribosomal protein S6 kinase 1,KS6B1,p70 alpha,P70 beta 1,p70 ribosomal S6 kinase alpha,p70 ribosomal S6 kinase beta 1,p70 S6 kinase alpha,P70 S6 Kinase,p70 S6 kinase,alpha 1,p70 S6 kinase,alpha 2,p70 S6K,p70 S6K-alpha,p70 S6KA,p70(S6K) alpha,p70(S6K)-alpha,p70-alpha,p70-S6K 1,p70-S6K,P70S6K,P70S6K1,p70S6Kb,PS6K,Ribosomal protein S6 kinase 70kDa polypeptide 1,Ribosomal protein S6 kinase beta 1,Ribosomal protein S6 kinase beta-1,Ribosomal protein S6 kinase I,RPS6KB1,S6K,S6K-beta-1,S6K1,Serine/threonine kinase 14 alpha,Serine/threonine-protein kinase 14A,STK14A,P70 S6 Kinase Mouse (1C7)抗体 |
| Swissprot | P23443 |
| Source | Mouse |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant Protein of P70 S6 Kinase of RPS6KB1 |
| Application | IHC-p(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:100-200 |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Cellular localization | Cytoplasm; Nucleus. Cytoplasm and Cell junction>synapse>synaptosome. Mitochondrion outer membrane. |
| Tissue specificity | Widely expressed. |
| Clone No | Clone:1C7 |
|---|---|
| Isotype | IgG |
| Purification | Protein A purification |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4. |
| Background | P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. |
