Pancreatic polypeptide/PPY Polyclonal Antibody
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN000330P
货期：咨询
宿主: Rat
反应性: H
应用: ELISA Capture/Detector
Overview
| Synonyms | Pancreatic poLypeptide prohormone;PH;Pancreatic poLypeptide Y;Pancreatic poLypeptide;Pancreatic icosapeptide;PPY;PNP |
| Swissprot | P01298 |
| Source | Rat |
| Reactivity | Human |
| Immunogen | Recombinant Human Pancreatic polypeptide/PPY protein expressed by E.coli |
| Application | ELISA Capture/Detector |
| Recommended dilution | ELISA Capture,,2-8 μg/mL;ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
Properties
| Isotype | IgG |
| Purification | Antigen Affinity Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Pancreatic polypeptide (PP),36-amino acid peptide,may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal,primarily protein,occurs in a biphasic manner. PP is a negative regulator of energy homeostasis that suppresses food intake and lowers body weight. Similar to other gastrointestinal-derived peptides,PP also modulates gastrointestinal motility and may be involved in the regulation of anxiety. PP,a robust anorexigenic hormone,effectively modulates food intake and energy homeostasis,thus potentially aiding anti-obesity therapeutics. PP is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand,central administration of PP elicits food intake and gastric emptying. |
