PAWR Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-15819
宿主: Rabbit
反应性: H
应用: WB
Overview
| Synonyms | 2310001G03Rik,PAR 4,PAR-4,Pawr,PAWR,PRKC Apoptosis WT1 Regulator,PRKC apoptosis WT1 regulator protein,Prostate apoptosis response 4 protein,Prostate apoptosis response protein 4,prostate apoptosis response protein PAR-4,Transcriptional repressor Par-4-like protein PAWR,Transcriptional repressor PAR4,WT1 Interacting Protein,PAWR抗体 |
| Swissprot | Q96IZ0 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Synthetic peptide of human PAWR |
| Application | WB(Detection kit: E-IR-R304) |
| Recommended dilution | WB,,1:500-1:2000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity). Nuclear localization includes nucleoplasm and PML nuclear bodies. |
| Tissue specificity | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. |
