PD-L1 Monoclonal Antibody(Detector)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN001390P
货期：咨询
宿主: Mouse
反应性: H
应用: ELISA Detector
Overview
| Synonyms | CD274;B7H1;PDCD1L1;PDCD1LG1;PDL1;PD-L1;Programmed ceLL death 1 Ligand 1;B7 homoLog 1;PDCD1 Ligand 1;Programmed death Ligand 1;hPD-L1 |
| Swissprot | Q9NZQ7 |
| Source | Mouse |
| Reactivity | Human |
| Immunogen | Recombinant Human PD-L1 L1 protein expressed by Mammalian |
| Application | ELISA Detector |
| Recommended dilution | ELISA Detector,,0.1-0.4 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 5A7 |
|---|---|
| Isotype | IgG2a |
| Purification | Protein A/G Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | Plays a critical role in induction and maintenance of immune tolerance to self.As a ligand for the inhibitory receptor PDCD1/PD-1,modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor,may costimulate T-cell subsets that predominantly produce interleukin-10 (Il10).Can also act as a transcription coactivator: in response to hypoxia,translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC,leading to pyroptosis.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system,thereby facilitating tumor survival.The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTls) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response,providing a rationale for cancer immunotherapy. |
