PHF21A Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-18538
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | BHC80a,BM-006,BRAF35-HDAC complex protein BHC80,BRAF35/HDAC2 complex (80 kDa),KIAA1696,PF21A,PHD finger protein 21A,PHF21A,PHF21A抗体 |
| Swissprot | Q96BD5 |
| Source | Rabbit |
| Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PHF21A |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:40-1:200; |
| Concentration | 0.6mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
| Background | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events. |
Images
Western blot analysis of 293T Hela and A375 cell lysates using PHF21A Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human prost at e cancer tissue using PHF21A Polyclonal Antibody at dilution of 1:50(×200)
Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PHF21A Polyclonal Antibody at dilution of 1:50(×200)
