PIM1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-14694
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Oncogene PIM 1,Oncogene PIM1,PIM 1,pim 1 kinase 44 kDa isoform,Pim 1 kinase,pim 1 oncogene (proviral integration site 1),Pim 1 oncogene,PIM,PIM1,pim1 kinase 44 kDa isoform,PIM1,Pim2,PIM3,Proto oncogene serine/threonine protein kinase Pim 1,Proto-oncogene serine/threonine-protein kinase Pim-1,Proviral integration site 1,Proviral integration site 2,PIM1抗体 |
| Swissprot | P11309 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human PIM1 |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:25-1:100 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus and Cell membrane. |
| Tissue specificity | Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons. |
