Plasminogen Activator/Urokinase Monoclonal Antibody(Capture)
| 规格： | / 25μg / 100μg |
| 价格： | / ￥800 / ￥2100 |
货号：AN002170P
货期：咨询
宿主: Rat
反应性: H
应用: ELISA Capture
Overview
| Synonyms | UPA;u-PA;ATF;URK;UP-A;Urokinase;Abbokinase; |
| Swissprot | P00749 |
| Source | Rat |
| Reactivity | Human |
| Immunogen | Recombinant Human Plasminogen Activator/Urokinase protein expressed by Mammalian |
| Application | ELISA Capture |
| Recommended dilution | ELISA Capture,,2-8 μg/mL |
| Concentration | 1mg/mL |
| Clonality | Monoclonal |
Properties
| Clone No | 7A1 |
|---|---|
| Isotype | IgG1 |
| Purification | Protein A/G Purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at 4°C Valid for 1 month or -20°C Valid for 12 months,Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Storage buffer | Sterile PBS,pH 7.4 |
| Background | This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
