PLPP1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12610
宿主: Rabbit
反应性: H,M,R
应用: IHC
Overview
| Synonyms | Lipid phosphate phosphohydrolase 1,Lipid phosphate phosphohydrolase 1a,LLP1a,LPP1,LPP1,PAP 2a,PAP-2a,PAP2,PAP2-alpha,PAP2a,PAP2a2,PAP2alpha2,PAPalpha1,Phosphatidate phosphohydrolase type 2a,Phosphatidic acid phosphatase 2a,Phosphatidic acid phosphatase type 2A,Phosphatidic acid phosphohydrolase type 2a,PPAP2A,Type 2 phosphatidic acid phosphatase alpha,Type 2 phosphatidic acid phosphohydrolase,PPAP2A抗体 |
| Swissprot | O14494 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human PPAP2A |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:50-1:200 |
| Concentration | 0.4 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cell membrane. |
| Tissue specificity | Ubiquitously expressed with highest expression found in prostate. Isoform 1 is predominant in kidney, lung, placenta and liver. Isoform 2 is predominant in heart and pancreas. Found to be down-regulated in colon adenocarcinomas. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. |
