POSTN Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40278
宿主: Rabbit
反应性: H
应用: IHC,IF
Overview
| Synonyms | Fasciclin-I like, MGC119510, MGC119511, OSF 2, OSF2, Osteoblast specific factor 2 (fasciclin I like), Osteoblast specific factor 2, PDLPOSTN, Periodontal ligament specific periostin, Periostin, Periostin isoform thy2, PN, POSTN,,POSTN抗体 |
| Swissprot | Q15063 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Periostin protein |
| Application | IHC(Detection kit: E-IR-R213),IF |
| Recommended dilution | IHC 1:100-1:200 IF 1:100-1:200 |
| Concentration | 0.79mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Secreted, extracellular matrix, Golgi apparatus |
| Tissue specificity | Widely expressed with Highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | Periostin (POSTN,PN),originally named as osteoblast-specific factor 2 (OSF-2),is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues,and has a role in bone,tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types,includidng lung,ovary,breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour,and it is required to allow cancer stem cell maintenance. |
Images
Immunohistochemistry of paraffin-embedded Human carcinoma of Colon using POSTN Polyclonal Antibody at dilution of 1:100(100×)
Immunohistochemistry of paraffin-embedded Human carcinoma of Colon using POSTN Polyclonal Antibody at dilution of 1:100(400×)
Immunohistochemistry of paraffin-embedded Human breast using POSTN Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded Human skin using POSTN Polyclonal Antibody at dilution of 1:80(Elabscience® Product Detected by Lifespan).
Immunofluorescence analysis of Hela cells using POSTN Polyclonal Antibody at dilution of 1:100
