POSTN Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-40279
宿主: Rabbit
反应性: H
应用: WB,IHC
Overview
| Synonyms | Fasciclin-I like,MGC119510,MGC119511,OSF 2,OSF-2,OSF2,Osteoblast specific factor 2 (fasciclin I like),Osteoblast specific factor 2,Osteoblast specific factor,Osteoblast-specific factor 2,PDLPOSTN,Periodontal ligament specific periostin,Periostin,Periostin isoform thy2,Periostin isoform thy4,Periostin isoform thy6,Periostin isoform thy8,Periostin osteoblast specific factor,PN,POSTN,POSTN,RP11 412K4.1,POSTN抗体 |
| Swissprot | Q15063 |
| Source | Rabbit |
| Reactivity | Human |
| Immunogen | Recombinant Human Periostin protein |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB 1:500-1:1000 IHC 1:100-1:200 |
| Concentration | 0.36mg/mL |
Properties
| Cellular localization | Secreted>extracellular space>extracellular matrix. |
| Tissue specificity | Widely expressed with Highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% Proclin300, 50% glycerol, pH7.3. |
| Background | Periostin (POSTN,PN),originally named as osteoblast-specific factor 2 (OSF-2),is a 90-kDa secreted protein which is now classified as a matricellular protein. It is present in a wide variety of normal adult tissues and fetal tissues,and has a role in bone,tooth and heart development and function. Studies show that periostin is overexpressed in a broad range of human cancer types,includidng lung,ovary,breast and colon cancers. Recent evidence reveals that periostin is expressed by fibroblasts in the normal tissue and in the stroma of the primary tumour,and it is required to allow cancer stem cell maintenance. |
