PPARA Polyclonal Antibody
| 规格： | / 60μL / 120μL / 200μL |
| 价格： | / ￥1380 / ￥2220 / ￥3300 |
货号：E-AB-70253
宿主: Rabbit
反应性: M,R
应用: IHC
Overview
| Synonyms | hPPAR,MGC2237,MGC2452,NR1C1,Nuclear receptor subfamily 1 group C member 1,OTTHUMP00000197740,OTTHUMP00000197741,Peroxisome proliferative activated receptor alpha,Peroxisome proliferator activated receptor alpha,Peroxisome proliferator-activated receptor alpha,PPAR,PPAR-alpha,ppara,PPARA,PPARalpha,PPARA抗体 |
| Swissprot | P23204,P37230 |
| Source | Rabbit |
| Reactivity | Mouse,Rat |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse PPARα |
| Application | IHC(Detection kit: E-IR-R213) |
| Recommended dilution | IHC,,1:200-1:500 |
| Concentration | 0.6 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus. |
| Tissue specificity | Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis.Highest expression level in jejunum. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.02% sodium azide,100 μg/ml BSA and 50% glycerol. |
| Background | Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase. |
Images
Immunohistochemistry analysis of paraffin-embedded mouse colon using PPARA Polyclonal Antibody at dilution of 1:300.
Immunohistochemistry analysis of paraffin-embedded mouse kidney using PPARA Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry analysis of paraffin-embedded rat liver using PPARA Polyclonal Antibody at dilution of 1:300.
