PRMT5 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-12625
宿主: Rabbit
反应性: H,M,R
应用: WB,IHC
Overview
| Synonyms | 72 kDa ICln binding protein,72 kDa ICln-binding protein,ANM5,Histone synthetic lethal 7,S. cerevisiae,homolog of,Histone-arginine N-methyltransferase PRMT5,HMT1 hnRNP methyltransferase like 5,HOMOLOG OF,SKB1,HRMT1L5,IBP72,Jak-binding protein 1,JBP 1,JBP1,PRMT 5,PRMT5,Protein arginine methyltransferase 5,Protein arginine N methyltransferase 5,Protein arginine N methyltransferase 5 N terminally processed,Protein arginine N-methyltransferase 5,S. POMBE,S. POMBE HOMOLOG OF,SKB1,SHK1 KINASE BINDING PROTEIN 1,Shk1 kinase binding protein 1 homolog,Shk1 kinase-binding protein 1 homolog,Shk1 kinase/binding protein 1,S. pombe,homolog of,SKB 1,SKB1,SKB1 homolog,SKB1: SKB1 homolog (S. pombe),SKB1Hs,PRMT5抗体 |
| Swissprot | O14744 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide of human PRMT5 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:200-1:1000; |
| Concentration | 0.3 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Cytoplasm. Nucleus. |
| Tissue specificity | Ubiquitous. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. |
Images
Western Blot analysis of K562, hela and 293T cell using PRMT5 Polyclonal Antibody at dilution of 1:400
Immunohistochemistry of paraffin-embedded Human breast cancer using PRMT5 Polyclonal Antibody at dilution of 1:20
Immunohistochemistry of paraffin-embedded Human tonsil using PRMT5 Polyclonal Antibody at dilution of 1:20
