PTCH1 Polyclonal Antibody
| 规格： | / 20μL / 60μL / 120μL / 200μL |
| 价格： | / ￥420 / ￥1010 / ￥1640 / ￥2365 |
货号：E-AB-10571
宿主: Rabbit
反应性: H,M
应用: WB,IHC
Overview
| Synonyms | PTC,BCNS,HPE7,PTC1,PTCH,NBCCS,PTCH11,PTCH1抗体 |
| Swissprot | Q13635 |
| Source | Rabbit |
| Reactivity | Human,Mouse |
| Immunogen | Recombinant protein of human PTCH1 |
| Application | WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213) |
| Recommended dilution | WB,,1:500-1:2000;IHC,,1:50-1:200; |
| Concentration | 0.5 mg/mL |
| Clonality | Polyclonal |
Properties
| Cellular localization | Nucleus,Plasma Membrane,caveola,ciliary membrane,plasma membrane,Other locations:axonal growth cone,dendritic growth cone,endocytic vesicle membrane,integral component of membrane,intracellular membrane-bounded organelle,midbody,perinuclear region of cytoplasm,postsynaptic density |
| Tissue specificity | In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin. |
| Isotype | IgG |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage instructions | Store at -20℃. Avoid freeze / thaw cycles. |
| Storage buffer | PBS with 0.05% sodium azide, 50% glycerol, PH7.3 |
| Background | This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. |
Images
Western Blot analysis of Hela cell and Mouse lung tissue using PTCH1 Polyclonal Antibody at dilution of 1:900
Immunohistochemistry of paraffin-embedded Human ovarian cancer using PTCH1 Polyclonal Antibody at dilution of 1:50
Immunohistochemistry of paraffin-embedded Human thyroid cancer using PTCH1 Polyclonal Antibody at dilution of 1:50
客户发表文献
- 文献: Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD
样品类型: Tissue homogenate
